Immune skills helped quicken healing in mice.

Wound care Centers defines a chronic wound as one that does not heal in the generally-expected timeframe, which a clinician determines to be appropriate for that wound type. For some wounds this is a couple of weeks, and for others it is closer to six weeks.

Individuals who suffer from chronic wounds may be encouraged to learn of new research from the Massachusetts General Hospital Vaccine and Immunotherapy Center. A group of scientists examined the manner in which immune cells accelerated healing of chronic woundsin diabetic mice.

Mature B lymphocytes are the immune cells that produce antibodies. The researchers took these cells from both diabetic and non-diabetic mice and after a single application, the wound healing process sped up. Additionally, the new tissue was of a higher quality, and the cells also helped heal chronic skin ulcers, reducing their size.

“Our demonstration that B lymphocytes – immune system cells that are abundant in the blood – can accelerate wound healing in both healthy and diabetic skin potentially opens up an exciting path to a new treatment for chronic wounds, such as diabetic foot ulcers,” Dr Ruxandra Sîrbulescu, PhD, of the MGH-VIC, lead and corresponding author of the report said.  “Diabetic foot ulcers are the most common cause of non-traumatic major amputations around the world and the costliest type of chronic wound to care for, so an inexpensive and safe way to accelerate healing would have great benefits.”

Individuals who suffer from diabetes can experience poor circulation which can lead to impaired healing. According to Wound Care Centers, diabetic ulcers can occur due to nerve damage or they can be ischemic in nature, meaning the skin is pale, cool and does not receive adequate blood, oxygen and nutrients.

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